Dr. Brindley has extensive national and international research experience (>180 peer reviewed publications). He is a graduate of the University of Queensland, Brisbane, Australia, completed post doctoral training at the NIAID's Laboratory of Parasitic Diseases, NIH, Bethesda, Maryland. He has held scientific and academic appointments at the Queensland Institute of Medical Research, Brisbane, Australia, University College Dublin, Ireland, and Tulane University Health Sciences Center, New Orleans, Louisiana.
Research
Research in our laboratory focuses the Neglected Tropical Diseases (NTDs) and NTD associated cancers. We are pursuing functional genomics and other approaches to characterize new interventions.
Current projects include:
- Transmission and activities of transgenes through the developmental stages of schistosomes
- Insertional mutagenesis analysis of schistosome chromosomes
- Transgene endowed antibiotic selection of schistosomes
- Growth factors of helminth parasites in carcinogenesis of liver fluke induced bile duct cancer and schistosomiasis haematobia associated bladder cancer.
- Human population studies in northeastern Thailand on pathogenesis and biomarkers of Opisthorchis viverrini (liver fluke) induced bile duct cancer, in collaboration with colleagues at Khon Kaen University, Thailand, and James Cook University and the Queensland Institute of Medical Research, Australia
- Studies originating in Angolan patients on pathogenesis of schistosomiasis haematobia associated bladder cancer, in collaboration with colleagues at the University of Porto, Portugal and others
For more information, please visit the Brindley Lab website
Centers and Institutes
Brindley PJ, Hotez PJ. (2013) Break out: Urogenital schistosomiasis and Schistosoma haematobium infection in the post-genomic era. PLOS Neglected Tropical Diseases 7(3): e1961.
You H, Hu W, Smout MJ, Brindley PJ, McManus DP, Gobert GN (2013) Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII. PLoS Pathogens 9(3): e1003254Berriman M, Brindley PJ (2012) Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by Murine Leukemia Virus. PLoS Pathogens 8(7): e1002820
Botelho MC, Vale N, Gouveia MJ, Rinaldi G, Santos J, Santos LL, Gomes P, Brindley PJ, Costa JM (2013) Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: An oestrogen–DNA adducts mediated pathway? International Journal for Parasitology 43, 17Brindley PJ (2012) Vasa–like DEAD-box RNA helicases of Schistosoma mansoni. PLoS Neglected Tropical Diseases 6(6): e1686
Young ND, Jex AR, Li B, Liu S, Yang L, Xiong Z, Li L, Cantacessi C, Hall RS, Xu X, Chen F, Wu X, Zerlotini A, Oliveira G, Hofmann A, Zhang G, Fang X, Kang Y, Campbell BE,
Suttiprapa S, Rinaldi G, Brindley PJ. (2012) Prototypic chromatin insulator cHS4 protects retroviral transgene from silencing in Schistosoma mansoni. Transgenic Research 21, 555- 566.
Rinaldi G, Eckert SE, Tsai IJ, Suttiprapa S, Kines KJ, Tort JF, Mann VH, Turner DJ, Berriman M, Brindley PJ (2012) Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by Murine Leukemia Virus. PLoS Pathogens 8(7): e1002820S, Loukas A, Brindley PJ, Sripa B. (2012) Ultrasonography assessment of hepatobiliary abnormalities in 3,359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand. Parasitology International 61, 208-211
Skinner, DE, Rinaldi G, Suttiprapa S, Mann VH, Smircich P, Cogswell AA, Williams DL, Brindley PJ (2012) Vasa–like DEAD-box RNA helicases of Schistosoma mansoni. PLoS Neglected Tropical Diseases 6(6): e1686schistosomes. PLoS Neglected Tropical Diseases 5(8):e1230
Young ND, Jex AR, Li B, Liu S, Yang L, Xiong Z, Li L, Cantacessi C, Hall RS, Xu X, Chen F, Wu X, Zerlotini A, Oliveira G, Hofmann A, Zhang G, Fang X, Kang Y, Campbell BE, Loukas A, Ranganathan S, Rollinson D, Rinaldi G, Brindley PJ, Yang H, Wang Y, Wang J, Gasser RB (2012) Whole-genome sequence of Schistosoma haematobium. Nature Genetics 44, 221trematodiases in Southeast Asia: epidemiology, pathology, clinical manifestation and control. Advances in Parasitology 72, 305-350
Mairiang E, Laha T, Bethony JM, Thinkhamrop B, Kaewkes S, Sithithaworn P, Tesana S, Loukas A, Brindley PJ, Sripa B. (2012) Ultrasonography assessment of hepatobiliary abnormalities in 3,359 subjects with Opisthorchis viverrini infection in endemic areas of Thailand. Parasitology International 61, 208parasite interactions in the horizontal transfer of transposons across phyla. Nature 464, 1347- 1350.
Okumura-Noji K, Miura Y, Asai K, Ohta N, Brindley PJ, Yokoyama S. (2013) CD36-Related protein in Schistosoma japonicum: Candidate mediator of selective cholesteryl ester uptake from high density lipoprotein for egg maturation. The FASEB Journal 27, 1236Gasser RB (2012) Whole-genome sequence of Schistosoma haematobium. Nature Genetics 44, 221-225.
Mann VH, Suttiprapa S, Rinaldi G, Brindley PJ. (2011) Establishing transgenic schistosomes. PLoS Neglected Tropical Diseases 5(8):e1230A. (2009) A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells. PLoS Pathogens 5(10):e1000611
Gilbert C, Schaak S, Pace II JK, Brindley PJ, Feschotte C. (2010) A role for host-parasite interactions in the horizontal transfer of transposons across phyla. Nature 464, 1347
Sripa B, Mairiang E, Thinkhamrop B, Laha T, Kaewkes S, Sithithaworn P, Tesana S, Loukas A, Brindley PJ, Bethony JM (2009) Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of IL-6. Hepatology 50(4), 1273 infections: the great neglected tropical diseases. Journal of Clinical Investigation 118, 1311- 1321
Smout, MJ, Laha T, Mulvenna J, Sripa B, Suttiprapa S, Jones A., Brindley PJ, Loukas A. (2009) A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells. PLoS Pathogens 5(10):e1000611
Hotez PJ, Brindley PJ, Bethony JM, Pearce EJ, King CH, Jacobsen J. (2008) Helminth infections: the great neglected tropical diseases. Journal of Clinical Investigation 118, 1311
Morales, M.E , Mann, V.H., Kines, K.J., Gobert, G.N., Kalinna, B.H., Fraser, M.J., Jr., Correnti, J.M., Pearce, E.J., Brindley, P.J. (2007) piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. The FASEB Journal 21, 3479
Sripa B, Kwaekes S, Sithithaworn P, Mairiang E, Laha T, Smout M, Pairojkul C, Bhudhisawasdi V, Tesana S, Thinkamrop B, Bethony JM, Loukas A, Brindley PJ 2007 Liver fluke induces cholangiocarcinoma. PLoS Medicine 4(7): e201