Dr. Pei is an Assistant Professor of Biochemistry and Molecular Medicine, the George Washington University School of Medicine & Health Sciences. He is interested in DNA damage response pathway, glycobiology and human diseases. He received his PhD from the Institute of Microbiology, Chinese Academy of Sciences, in molecular biology of DNA replication. As a postdoctoral fellow at Mayo Clinic, he expanded his research scope to DNA damage response and human diseases. Since he became an independent investigator at GW, Dr. Pei has led a productive research team in several areas, including DNA damage response, glycobiology and cancer cell metabolism.
Dr. Pei's laboratory focuses on understanding DNA damage response pathway, which is critical for maintaining genomic stability. DNA damage agents, such as ubiquitous UV and ionising radiation, activate a signaling cascade called DNA damage response pathway that initiates DNA repair and cell cycle checkpoint activation. Understanding this pathway will help us understand the cause of genomic instability, a driving force of tumorigenesis. In addition, we could explore the information gained to effectively kill cancer cells, since cancer cells often are defective in some aspect of DNA damage response.
Dr. Pei's laboratory is also interested in glycobiology and human diseases. Nutrient flux into the cell triggers protein modification by the amino sugar called N-acetylglucosamine (O-GlcNAc). This dynamic and reversible posttranslational modification is emerging as a key regulator of diverse cellular processes. We are interested in elucidating how dysregulation in this posttranslational modification contributes to human diseases including cancer, neurodegenerative diseases, obesity and aging.
We are employing a combination of experimental approaches, including biochemistry, cellular biology, mouse genetics, proteomics and metabolomics, to accomplish our research goals.