Brian Rood, MD
Affiliation: Cancer Biology Research Program, Children's National Hospital
Research Summary:

The Rood lab is investigating the proteome of medulloblastoma, the most common malignant brain tumor of childhood, in order to determine the differences between the four subgroups of the disease in an effort to identify therapeutic targets. We are also using a proteogenomic approach to identify translated cancer specific genomic alterations such as fusions and splice isoforms. We aim to further this work by developing circulating tumor DNA assays to detect medulloblastoma specific DNA variants in the blood and cerebrospinal fluid in order to discover biomarkers capable of measuring therapeutic efficacy and detecting recurrent disease. Lastly, our lab is working to identify microsatellite markers in a person's DNA that predict the risk of developing different kinds of brain tumors.